If you are coming from France and don't want to pay the taxes for the swiss highways, you can leave the highway before you cross the border (Saint-Julien), and drive the last kilometers on the road (10 minutes).

From the BnB, a 5 minutes walk takes you to the public transport system : a shuttle bus and a tramway (line 14) will help you to reach Geneva downtown, the railway station, or the UNO very easily.